TITLE

Neoplasia free papers

PUB. DATE
April 2005
SOURCE
Gut;Apr2005 Supplement 2, Vol. 54, pA29
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
The article presents information on abstracts related to neoplasia. An abstract informs that ZD6474 significantly reduces polyp burden in a mouse model of intestinal cancer. ZD6474, an orally active inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor (EGFR) tyrosine kinase activity, was used to study the effect of blocking angiogenesis and EGFR signalling in multiple intestinal neoplasia mice. These mice develop numerous benign polyps due to a mutation of the adenomatous polyposis coli gene, as in familial adenomatous polyposis in humans.
ACCESSION #
16567963

 

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