Cell/molecular biology free papers

April 2005
Gut;Apr2005 Supplement 2, Vol. 54, pA24
Academic Journal
The article presents information on abstracts related to cell and molecular biology. An abstract persents information on clusters of phenotypically related human colonic crypts develop through crypt fission. It has been proposed that colorectal cancer is caused by the accumulation of DNA mutations in colonic stem cells. Crypt fission, a crypt splitting to form two daughter crypts, is a likely method by which these mutations spread through the colon. Crypts within close proximity to each other should therefore be genetically related. Mitochondrial cytochrome c oxidase subunit was used as a marker of crypt clonality, as mtDNA has a relatively high mutation rate compared to nuclear DNA.


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