Pathology/IBD symposium

April 2005
Gut;Apr2005 Supplement 2, Vol. 54, pA17
Academic Journal
The article presents information on abstracts related to pathology. One abstract focuses on decreased telomeric repeat binding factor 2 (TRF2) expression in resting peripheral blood lymphocytes in ulcerative colitis. TRF2 stabilizes mammalian telomeres and acts independently of telomerase. Decreased expression results in telomeric fusion and chromosomal instabilily leading to cell death or carcinogenesis. Such cytogenetic abnormalities are present in peripheral blood lymphocytes of patients with ulcerative colitis (UC) and other inflammatory diseases. In the colonic mucosa in UC, similar changes precede progression to dysplasia and cancer. TRF2 may also have a role in DNA repair processes, because it is upregulated upon activation of cells with damaged DNA.


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