TITLE

Pathology/IBD symposium

PUB. DATE
April 2005
SOURCE
Gut;Apr2005 Supplement 2, Vol. 54, pA17
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
The article presents information on abstracts related to pathology. One abstract focuses on decreased telomeric repeat binding factor 2 (TRF2) expression in resting peripheral blood lymphocytes in ulcerative colitis. TRF2 stabilizes mammalian telomeres and acts independently of telomerase. Decreased expression results in telomeric fusion and chromosomal instabilily leading to cell death or carcinogenesis. Such cytogenetic abnormalities are present in peripheral blood lymphocytes of patients with ulcerative colitis (UC) and other inflammatory diseases. In the colonic mucosa in UC, similar changes precede progression to dysplasia and cancer. TRF2 may also have a role in DNA repair processes, because it is upregulated upon activation of cells with damaged DNA.
ACCESSION #
16567953

 

Related Articles

  • Surveillance B lymphocytes and mucosal immunoregulation. Velázquez, Peter; Wei, Bo; Braun, Jonathan // Springer Seminars in Immunopathology;Mar2005, Vol. 26 Issue 4, p453 

    Mucosal lymphocyte homeostasis involves the dynamic interaction of enteric microbiota, the intestinal host epithelium, and the mucosal immune system. Dysregulation of mucosal lymphocyte homeostasis results in a variety of intestinal disorders, notably inflammatory bowel diseases like ulcerative...

  • Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment. Arijs, Ingrid; De Hertogh, Gert; Machiels, Kathleen; Van Steen, Kristel; Lemaire, Katleen; Schraenen, Anica; Van Lommel, Leentje; Quintens, Roel; Van Assche, Gert; Vermeire, Séverine; Schuit, Frans; Rutgeerts, Paul // American Journal of Gastroenterology;Apr2011, Vol. 106 Issue 4, p748 

    OBJECTIVES:Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed. This study investigated the effect of infliximab therapy...

  • Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis. Thomas, Saskia; Baumgart, Daniel // Inflammopharmacology;Feb2012, Vol. 20 Issue 1, p1 

    Crohn's disease and ulcerative colitis are two chronic inflammatory bowel diseases. Current biologic therapies are limited to blocking tumor necrosis factor alpha. However, some patients are primary non-responders, experience a loss of response, intolerance or side effects defining the urgent...

  • Recent Understanding of Leukocytapheresis (LCAP) for the Treatment of Inflammatory Bowel Disease. Mitsuyama, Keiichi; Yamasaki, Hiroshi; Kuwaki, Kotaro; Takedatsu, Hidetoshi; Sata, Michio // Current Pharmaceutical Design;6/21/2009, Vol. 15 Issue 18, p2110 

    Inflammatory bowel disease (IBD) is frequently associated with the infiltration of a large number of leukocytes into the bowel mucosa. Therefore, the removal of circulating leukocytes may be an attractive approach for the treatment of IBD. Leukocytapheresis with Cellsorba, a column of...

  • Primary Sclerosing Cholangitis and IBD. Cholongitas, Evangelos; Theocharidou, Eleni; Burroughs, Andrew K. // Inflammatory Bowel Disease Monitor;2012, Vol. 12 Issue 3, p110 

    The association between primary sclerosing cholangitis (PSC) and IBD is well documented, and the IBD in these cases may represent a distinct disease phenotype. Up to 90% of patients with PSC have IBD, usually ulcerative colitis (UC), while IBD is accompanied by PSC in approximately 5% of IBD...

  • Mechanisms Underlying the Effects of Leukocyte Apheresis with a Fiber Filter in a Rat Model of Dextran Sulfate Sodium-Induced Colitis. Yamasaki, Hiroshi; Mitsuyama, Keiichi; Masuda, Junya; Tomiyasu, Nobuo; Takedatsu, Hiroko; Akashi, Hirotada; Matsumoto, Satoshi; Takedatsu, Hidetoshi; Kuwaki, Kotaro; Tsuruta, Osamu; Sata, Michio // Digestive Diseases & Sciences;Mar2010, Vol. 55 Issue 3, p596 

    While several clinical trials have suggested that leukocytapheresis (LCAP) by filtration can benefit patients with active ulcerative colitis, the mechanisms underlying these benefits are largely unknown. The aim of this study was to address the mechanisms that may underlie the therapeutic...

  • Shining a Light on Intestinal Traffic. Murphy, Carola T.; Nally, Kenneth; Shanahan, Fergus; Melgar, Silvia // Clinical & Developmental Immunology;2012, p1 

    Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. Thus, leukocyte trafficking is a major target for IBD therapy. Past and...

  • Activated platelets as a possible early marker to predict clinical efficacy of leukocytapheresis in severe ulcerative colitis patients. Fukunaga, Ken; Fukuda, Yoshihiro; Yokoyama, Yoko; Ohnishi, Kunio; Kusaka, Takeshi; Kosaka, Tadashi; Hida, Nobuyuki; Ohda, Yoshio; Miwa, Hiroto; Matsumoto, Takayuki // Journal of Gastroenterology;Jun2006, Vol. 41 Issue 6, p524 

    Background. Leukocytapheresis (LCAP) is an effective adjunct for patients with active ulcerative colitis (UC). Because LCAP may have the potential to remove and modulate not only leukocytes but also platelets, we evaluated the correlation between activated platelets and the therapeutic response...

  • The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity. Noguchi, Atsushi; Watanabe, Kenji; Narumi, Shosaku; Yamagami, Hirokazu; Fujiwara, Yasuhiro; Higuchi, Kazuhide; Oshitani, Nobuhide; Arakawa, Tetsuo // Journal of Gastroenterology;Dec2007, Vol. 42 Issue 12, p947 

    To clarify which types of cells produce interferon-γ-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients. Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics