Doherty, G. A.; Collins, K.; Sweeney, M. R.; Byrne, S. M.; Aftab, A. R.; Kay, E. W.; Murray, F. E.; Shields, D. C.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA18
Academic Journal
This article evaluates the relationship between methylenetetrahydrofolate reductase (MTHFR) expression in colorectal tumour tissue and the C677T polymorphism. Folate supplementation appears to reduce colorectal cancer (CRC) risk. CRC risk is also modulated by the C to T polymorphism at position 677 of the MTHFR gene, which results in a thermolabile variant of MTHFR and is associated with reduced cellular bide levels. 39 patients with colorectal cancer were studied. DNA was extracted from citrated blood and tumour tissue and genotyped for the MTHFR C677T polymorphism.


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