TITLE

EX VIVO SENTINEL LYMPH NODE MAPPING IN COLORECTAL CARCINOMA, A NOVEL APPROACH THAT IDENTIFIES OCCULT TUMOUR SPREAD

AUTHOR(S)
Smith, F. M.; Coffey, J. C.; Khasri, N.; Galvin, E.; Walsh, M.; El Sayed, A.; O'Connor, O. J.; Malone, C.; Parfrey, N.; Goffney, E.; Stephens, R.; Kennedy, M. J.; Reynolds, J. V.; Kirwan, W. O.; Redmond, H. P.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA17
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
This article focuses on a study that established a novel ex vivo mapping technique that is easily applicable both in theatre and also during histological processing. The development of systemic disease after curative surgery for colorectal cancer approaches 30%. This may represent understaging. Sentinel lymph node mapping (SLNM) identifies lymph nodes at high risk of harbouring metastatic disease. With full ethical approval and informed consent, 27 patients with primary colorectal cancer and 3 patients with severely dysplastic tubulovillous adenomas prospectively underwent ex vivo SLNM.
ACCESSION #
13218879

 

Related Articles

  • 1st Biennial Meeting of the Eurasian Colorectal Technologies Association (ECTA), 13-15 November 2009, Guangzhou/Canton, China.  // Techniques in Coloproctology;Mar2010, Vol. 14 Issue 1, p57 

    The article presents several abstracts on medical topics discussed at the 1st biennial meeting of the Eurasian Colorectal Technologies Association (ECTA) in China which includes the diagnosis and management of complications of the ileal pouch, concept of multidisciplinary treatment for...

  • PRELIMINARY STUDY OF LYMPHATIC CHANNEL DENSITY IN COLORECTAL ADENOCARCINOMA. R. N., Venkatesh; E. S., Ch'ng; J., Hasnan // Malaysian Journal of Medical Sciences;Jan2008 Supplement, p213 

    Objective: To determine the number of lymphatic channels present in colorectal adenocarcinoma and to correlate it with the site, size, stage of tumor and also with lymph node metastasis. Material & Method: A total of 29 cases were retrieved from the archives of the Pathology Department, School...

  • LYMPHADENECTOMY IN COLORECTAL CARCINOMA: REVIEW OF THE LITERATURE. KISS, LORAND; PORR, PAUL-JÜRGEN; KISS, ROLAND; KOVACS, CSILLA; BOICEAN, ADRIAN; ZAHARIA, SORIN // Acta Medica Transilvanica;sep2013, Vol. 18 Issue 3, p370 

    Soon we will be able to stage patients without needing to remove the primary tumour and surrounding lymphatic tissue. Soon we will be able to predict which primary tumours have a predisposition to metastasize and where they will metastasize. Colon and rectal cancer continue to be among the...

  • A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes. Fumagalli, Debora; Gavin, Patrick G.; Taniyama, Yusuke; Seung-Il Kim; Hyun-Joo Choi; Soonmyung Paik; Pogue-Geile, Katherine L. // BMC Cancer;2010, Vol. 10, p101 

    Background: An increasing number of studies show that genetic markers can aid in refining prognostic information and predicting the benefit from systemic therapy. Our goal was to develop a high throughput, costeffective and simple methodology for the detection of clinically relevant hot spot...

  • Passive Seeding in Metanephric Adenoma: A Review of Pseudometastatic Lesions in Perinephric Lymph Nodes. Paner, Gladell P.; Turk, Thomas M.; Clark, Loseph I.; Lindgren, Valerie; Picken, Maria M. // Archives of Pathology & Laboratory Medicine;Oct2005, Vol. 129 Issue 10, p1317 

    Lymph node involvement derived from a discrete neo-plastic process fundamentally implies tumor malignancy. However, rarely, inconsequential passive transport of benign neoplastic cells to the lymph node can occur and may cause confusion as to the nature of the neoplasm (ie, malignant vs benign)....

  • The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer. Yan, Qin; Yuan, Yin; Yankui, Liu; Jingjie, Feng; Linfang, Jin; Yong, Pu; Dong, Hua; Xiaowei, Qi // Cell Biochemistry & Biophysics;Sep2015, Vol. 73 Issue 1, p253 

    The objective of the study is to investigate the CXCR5 and MMP-13 expression in colorectal cancer and explore its correlation between the clinicopathological characteristics and prognosis. The expressions of CXCR5 and MMP-13 proteins in 236 paired specimens of colorectal cancer and incisal edge...

  • Lymph node harvests directly influence the staging of colorectal cancer: evidence from a regional audit. Pheby D F H; Levine D F; Pitcher R W; Shepherd N A // Journal of Clinical Pathology;Jan2004, Vol. 57 Issue 1, p43 

    AIMS: To assess the quality of histopathology reporting and accuracy of Dukes's staging of colorectal cancers in the former South Western Health region and to determine the impact of numbers of lymph nodes examined on stage ascription. METHODS: Histopathology reports of colorectal cancer for...

  • Lymph Node Correlations and Thresholds in Colorectal Cancer Specimens. Minhas, Jatinder S.; Igali, Laszlo // International Journal of Surgical Pathology;Aug2011, Vol. 19 Issue 4, p462 

    Lymph node yield is a key factor in enabling the accurate determination of prognosis in colorectal cancer patients. The Royal College of Pathologists guidelines state a “minimum” recommended mean number of 12 lymph nodes. In this study of 391 patients, the authors aim to determine...

  • The complexity of the count: considerations regarding lymph node evaluation in colorectal carcinoma. Denham, Laura J.; Kerstetter, Justin C.; Herrmann, Paul C. // Journal of Gastrointestinal Oncology;Dec2012, Vol. 3 Issue 4, p342 

    In patients with colorectal carcinoma, studies have reported improved survival with increasing numbers of retrieved lymph nodes. These findings are puzzling, as increased node sampling was not correlated with significant change in disease staging. Although the physiologic processes underlying...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics