TITLE

ROLE OF CYTOKINE GENE POLYMORPHISMS IN COLORECTAL CANCER AND THEIR INTERACTION WITH ASPIRIN USE IN THE NORTH EAST OF SCOTLAND

AUTHOR(S)
Macarthur, M.; Sharp, L.; Hold, G. L.; Little, J.; El-Omar, E. M.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA17
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
This article evaluates the role of pro- and anti-inflammatory cytokine genes polymorphisms in colorectal cancer (CRC) in the northeast of Scotland and to study their regular interaction with regular aspirin use. Chronic inflammation increases the risk of many malignancies including CRC. This risk is reduced significantly by regular use of COX inhibitors such as aspirin and NSAIDs, suggesting that inflammation plays a key role in the pathogenesis of CRC. There is strong evidence that pro-inflammatory cytokine gene polymorphisms increase the risk of several cancers including gastric adenocarcinoma.
ACCESSION #
13218878

 

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