TITLE

THE SOURCE OF WNT EXPRESSION IN THE COLON: SUBEPITHELIAL MYOFIBROBLASTS AND THE MAINTENANCE OF THE STEM CELL NICHE

AUTHOR(S)
Bamba, S.; Otto, W. R.; Lee, C. Y.; Brittan, M.; Wright, N. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA17
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
This article shows the contribution of colonic sub-epithelial microfibroblasts are the source of Wnt signaling in the colon. Wnt signaling is known to play an important role in the various stages of embryogenesis and carcinogenesis. Recent reports have implicated that Wnt proteins could act as growth factors, maintaining the stem cell phenotype and even controlling the symmetry of stem cell divisions. The Wnt family consists of 19 different genotypes in humans and the mouse. The source of Wnt signaling and its regulation is obscure.
ACCESSION #
13218877

 

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