March 2001
Nature Reviews Molecular Cell Biology;Mar2001, Vol. 2 Issue 3, p163
Academic Journal
Presents abstracts of studies relating to apoptosis, DNA repair, membrane dynamics, cytoskeleton and cell cycle. "Human DNA Repair Genes," by R.D. Wood; "Genomics, the Cytoskeleton and Motility," by T.D. Pollard; "Can Sequencing Shed Light on Cell Cycling?," by A.W. Murray and D. Marks.


Related Articles

  • Characterization and expression pattern of p53 during spermatogenesis in the Chinese mitten crab Eriocheir sinensis. Hou, Cong-Cong; Yang, Wan-Xi // Molecular Biology Reports;Feb2013, Vol. 40 Issue 2, p1043 

    p53, as a 'Guardian of the Genome', plays an important role in cell cycle arrest, apoptosis, DNA repair and inhibition of angiogenesis in different tissues including testis. p53 gene and its protein perform many essential roles for mammalian spermatogenesis. To explore its functions during...

  • Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regulating apoptosis, cell cycle and DNA repair. Klein, A.; Miera, O.; Bauer, O.; Golfier, S.; Schriever, F. // Leukemia (08876924);Jan2000, Vol. 14 Issue 1, p40 

    B cell chronic lymphocytic leukemia (B-CLL) cannot be cured with conventional chemotherapy. This clinical enigma appears to be at least partially due to the fact that B-CLL cells are resistant to programmed cell death (apoptosis) and that they are arrested in G0/G1 phase of the cell cycle. The...

  • Tumour suppressor p53: understanding the molecular mechanisms inherent to cancer. Kumari, Rajni; Sen, Nirmalya; Das, Sanjeev // Current Science (00113891);9/10/2014, Vol. 107 Issue 5, p786 

    Tumour suppressor p53 has been the centre of focus of researchers trying to decipher the molecular mechanisms underlying tumourigenesis. In this review, we have summarized the critical role of p53 in tumour suppression through its effects on several cellular processes such as DNA repair, cell...

  • Response to DNA damage: why do we need to focus on protein phosphatases? Shimada, Midori; Nakanishi, Makoto // Frontiers in Oncology;Jan2013, Vol. 3, p1 

    Eukaryotic cells are continuously threatened by unavoidable errors during normal DNA replication or various sources of genotoxic stresses that cause DNA damage or stalled replication. To maintain genomic integrity, cells have developed a coordinated signaling network, known as the DNA damage...

  • Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice. Petibone, Dayton; Kulkarni, Rohan; Chang, Ching-Wei; Chen, James; Morris, Suzanne // Transgenic Research;Apr2012, Vol. 21 Issue 2, p257 

    Our laboratory is conducting experiments designed to characterize the role of p53 in gene expression in the TSG-p53® mouse model. In the study reported here, gene expression levels in tissue derived from the testis, liver, and heart of male, 8-9 week old, p53 wild-type (WT), heterozygous...

  • Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Amundson, Sally A.; Myers, Timothy G.; Fornace, Jr., Albert J. // Oncogene;12/24/98 Review, Vol. 17 Issue 25, p3287 

    The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular stress response, in part through the transcriptional activation of genes involved in cell cycle control, DNA repair, and apoptosis. Many factors contribute to control of the activation of p53, and the...

  • Gadd45 in stress signaling. Liebermann, Dan A.; Hoffman, Barbara // Journal of Molecular Signaling;2008, Vol. 3, Special section p1 

    Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a...

  • Biological functions of the ING family tumor suppressors. Campos, E. I.; Chin, M. Y.; Kno, W. H.; Li, G. // Cellular & Molecular Life Sciences;Oct2004, Vol. 61 Issue 19/20, p2597 

    Early studies of the inhibitor of growth 1 (ING1) gene, the founding member of theINGtumor suppressor family, demonstrated that this gene plays an important role in apoptosis and cellular senescence. Four other related genes have since been identified and found to be involved in various...

  • Regulation of DNA repair throughout the cell cycle. Branzei, Dana; Foiani, Marco // Nature Reviews Molecular Cell Biology;Apr2008, Vol. 9 Issue 4, p297 

    The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics