March 2001
Nature Reviews Molecular Cell Biology;Mar2001, Vol. 2 Issue 3, p167
Academic Journal
Presents abstracts of studies on cell signaling, DNA recombination and DNA repair. "A High Signal-to-Noise Ca²+; Probe Composed of a Single Green Fluorescent Protein," by J. Nakai, M. Ohkura and K. Imoto; "Branch Migration and Holliday Junction Resolution Catalyzed by Activities From Mammalian Cells," by A. Constantinou, A.A. Davies and S.C. West; "XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair," by C.J. Whitehouse, et al.


Related Articles

  • Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Bellacosa, A // Cell Death & Differentiation;Nov2001, Vol. 8 Issue 11, p1076 

    The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. This function is critically dependent on the assembling of multimeric complexes involved in mismatch...

  • The MRE11 complex: starting from the ends. Stracker, Travis H.; Petrini, John H. J. // Nature Reviews Molecular Cell Biology;Feb2011, Vol. 12 Issue 2, p90 

    The maintenance of genome stability depends on the DNA damage response (DDR), which is a functional network comprising signal transduction, cell cycle regulation and DNA repair. The metabolism of DNA double-strand breaks governed by the DDR is important for preventing genomic alterations and...

  • The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Gareau, Jaclyn R.; Lima, Christopher D. // Nature Reviews Molecular Cell Biology;Dec2010, Vol. 11 Issue 12, p861 

    Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have...

  • Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea. Lewis, Patrick A.; Hardy, John; Martins, L. Miguel; Wood, Nicholas W.; Plun-Favreau, Hélène // PLoS Genetics;Dec2010, Vol. 6 Issue 12, Special section p1 

    No abstract available.

  • Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells. Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin M.; Våtsveen, Thea K.; Rø, Torstein B.; Bellacchio, Emanuele; Sundan, Anders; Otterlei, Marit // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous nature of the malignancy. Proliferating cell nuclear antigen (PCNA) is a...

  • Ubiquitous points of control over regulatory T cells. Pan, Fan; Barbi, Joseph // Journal of Molecular Medicine;Jun2014, Vol. 92 Issue 6, p555 

    Posttranslational modification by ubiquitin tagging is crucial for regulating the stability, activity and cellular localization of many target proteins involved in processes including DNA repair, cell cycle progression, protein quality control, and signal transduction. It has long been...

  • How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability. Jeggo, Penny A.; Löbrich, Markus // Biochemical Journal;10/1/2015, Vol. 471 Issue 1, p1 

    DNA DSBs (double-strand breaks) are a significant threat to the viability of a normal cell, since they can result in loss of genetic material if mitosis or replication is attempted in their presence. Consequently, evolutionary pressure has resulted in multiple pathways and responses to enable...

  • The CK1 family: contribution to cellular stress response and its role in carcinogenesis. Uwe Knippschild; Krüger, Marc; Richter, Julia; Pengfei Xu; García-Reyes, Balbina; Peifer, Christian; Halekotte, Jakob; Vasiliy Bakulev; Bischof, Joachim // Frontiers in Oncology;May2014, Vol. 4, p1 

    Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play major regulatory roles in many cellular processes including DNA-processing and repair, proliferation, cytoskeleton dynamics, vesicular trafficking, apoptosis, and cell differentiation. As a consequence of...

  • Nimotuzumab Enhances the Radiosensitivity of Cancer Cells In Vitro by Inhibiting Radiation-Induced DNA Damage Repair. Qu, Yuan-yuan; Hu, Song-liu; Xu, Xiang-ying; Wang, Rui-zhi; Yu, Hong-yang; Xu, Jian-yu; Chen, Lin; Dong, Guang-lu // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Background: Nimotuzumab is a humanized IgG1 monoclonal antibody specifically targeting EGFR. In this study, we aimed to investigate the molecular mechanisms of nimotuzumab in its effects of enhancing cancer cell radiosensitivity. Principal Finding: Lung cancer A549 cells and breast cancer MCF-7...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics