Utekhin, V. J.
September 2015
Vestnik Sankt-Peterburgskogo Universiteta, Seriia 11: Medicina;2015, Issue 2, p12
Academic Journal
Changes in different parts of pancreatic epithelium (acini surrounding the islets, common acini, intercalated ducts and centroacinar cells, intra and interlobular ducts, small, medium and large pancreatic islets) have been studied under hypothyroid condition using thyroidectomy as a model of hypothyroidism. Thyroidectomy gave rise to the retardation in the growth of body weight in experimental animals, the suppression of DnA synthesis in nuclei and 35s -- methionine incorporation into cytoplasm of exocrine cells (acini surrounding the islets and common acini), the increase in the total islet volume (+61% on 30th day after thyroidectomy) and b/A -- cell volume ratio in pancreatic islets of middle classes, simultaneously, the suppression of DnA synthesis in the nuclei of islet cells in small pancreatic islets and also the incorporation of 35s -- methionine into cytoplasm of islet cells of all classes of pancreatic islets was observed. At the same time, a marked increase was revealed in the number of "mixed" (exo -- endocrine) cells in pancreatic islets, in acini surrounding the islets, in common acini and in duct epithelium. At early stages after thyroidectomy islet b -- cells were "light" ones with weak signs of synthetic activity, with signs of secretion and with increased number of granulolysis figures. After 30 days of experiment islet Bcells were mainly "light" bcells, accumulating secretory granules. "Dark" bcells (cells with actively synthetic function) were seldom observed, both A and Bcells show the trend towards the growth of myelin figures, crinophagic vacuoles and lysosomes in their cytoplasm.


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