Datsenko, S. V.; Bautin, A. E.; Tashkhanov, D. M.; Marichev, A. O.; Bakanov, A. Yu.; Malaya, E. Ya.; Naumenko, V. S.; Gordeev, M. L.
September 2015
Vestnik Sankt-Peterburgskogo Universiteta, Seriia 11: Medicina;2015, Issue 2, p9
Academic Journal
The aim. to estimate whether remote ischemic preconditioning (RIpe) affects the inflammatory response and clinical course in patients undergoing aortic valve replacement (AVR). Materials and Methods. 48 patients aged 50 to 75 years which were scheduled for AVR due to aortic valve stenosis were included into the prospective, randomized study. Four groups were formed after randomization: 1) RIpe applied during propofol anesthesia (RIpcprop, n = 12), 2) RIpe applied during sevoflurane anesthesia (RIpcsevo, n = 12), 3) propofol anesthesia without RIpe (contRoLprop, n = 12), 4) sevoflurane anesthesia without RIpe (contRoLsevo, n = 12). RIpe protocol: three fiveminutes episodes of simultaneous both lower limbs ischemia with fiveminutes reperfusion intervals. IL6, IL8 and cRp levels were assessed prior to induction of anesthesia, at 30 min, 6, 12, 24 and 48 hours after the cessation of cpb. significant differences were assessed by the nonparametric MannWhitney and Fisher's exact tests. Results. There were no statistical differences in cRp, IL8 and IL6 concentrations between the RIpe and contRoL groups at 30 min, 12 h and 48 h after cpb. Unexpectedly we found significantly higher IL8 activity in the RIpe group at 24 h after cpb. It was 11,9(10,3; 14,9) pg/ml vs. 8,1 (5,7; 10,5) pg/ml in the contRoL group (p =0,01). significant excess concentrations of IL8 at 24 h were found when RIpe applied during sevoflurane anesthesia: 12,3 (10,6, 14,4) pg/mL in RIpcsevo group vs 6.2 (4,8, 11,1) pg/ ml in contRoLsevo group (p = 0,02), there were no differences in IL8 concentrations between RIpcprop and contRoLprop groups in all time points. Conclusion. This pilot study indicates surprisingly that RIpe may enhance the inflammatory response after AVR.


Related Articles

  • Direct transcatheter aortic valve implantation -- one-year outcome of a case control study. Kochman, Janusz; Kołtowski, Łukasz; Huczek, Zenon; Scisło, Piotr; Bakoń, Leopold; Wilimski, Radosław; Rymuza, Bartosz; Opolski, Grzegorz // Advances in Interventional Cardiology;2014, Vol. 10 Issue 4, p250 

    Introduction: Transaortic valve implantation (TAVI) has a well-established position in the treatment of high-risk and inoperable patients with severe aortic stenosis (AS). The TAVI protocol requires a pre-dilatation for native valve preparation. Aim: To assess the safety and feasibility of TAVI...

  • Position Statement for the Operator and Institutional Requirements for a Transcatheter Aortic Valve Implantation (TAVI) Program. Walters, Darren L.; Webster, Mark; Pasupati, Sanjeevan; Walton, Antony; Muller, David; Stewart, Jim; Williams, Michael; MacIsaac, Andrew; Scalia, Greg; Wilson, Michael; Gamel, Adam El; Clarke, Andrew; Bennetts, Jayme; Bannon, Paul // Heart, Lung & Circulation;Mar2015, Vol. 24 Issue 3, p219 

    The Cardiac Society of Australia and New Zealand (CSANZ) and the Australia and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) have joined together to provide recommendations for institutions and individual operators to assess their ability to initiate and maintain a transcatheter...

  • The transcatheter aortic valve implementation (TAVI)--a qualitative approach to the implementation and diffusion of a minimally invasive surgical procedure. Merkel, Sebastian; Eikermann, Michaela; Neugebauer, Edmund A.; von Bandemer, Stephan // Implementation Science;10/7/2015, Vol. 10 Issue 1, p1 

    Background: The transcatheter aortic valve implantation (TAVI), a minimally invasive surgical procedure to treat patients with severe symptomatic aortic stenosis, showed a rapid diffusion in Germany compared to the international level. The aim of this study is to identify and...

  • Transcatheter Aortic Valve Replacement. Jin, Jill // JAMA: Journal of the American Medical Association;11/19/2014, Vol. 312 Issue 19, p2059 

    The article focuses on the use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis. Topics discussed include open heart surgery's role as the traditional method for aortic valve replacement, the U.S. Food and Drug Administration's (FDA) approval of TAVR in 2011 for people...

  • TAVR update: Contemporary data from the UK TAVI and US TVT registries. Suradi, Hussam S.; Hijazi, Ziyad M. // Global Cardiology Science & Practice;2015, Vol. 2015 Issue 2, p1 

    The introduction of transcatheter aortic valve replacement (TAVR in US - TAVI in Europe) has resulted in a paradigm shift in the treatment of patients with severe aortic stenosis. Although three randomized trials and multiple single-center and multicenter registry studies have been published,...

  • TAVI or AVR in severe aortic stenosis in the USA?  // PharmacoEconomics & Outcomes News;3/3/2012, Issue 648, p7 

    The article deals with a study which concluded that compared with tissue aortic valve replacement (AVR), transcatheter aortic valve implantation without replacement (TAVI) is more cost effective in high-risk patients with severe aortic stenosis in the U.S.

  • Late sequela of aortotomy in infancy: supravalvular aortic stenosis and aneurysmal changes of epiaortic branches. Maeda, Shusaku; Numata, Satoshi; Nishida, Koichi; Tsutsumi, Yasushi // European Journal of Cardio-Thoracic Surgery;Feb2015, Vol. 47 Issue 2, p386 

    The article presents a case study of a 22-year lady with late sequela of aortotomy in infancy who underwent aortic root and arch replacement branches after computed tomography showed supravalvular aortic stenosis and aneurysmal changes of epiaortic branches.

  • Technical Aspects of the Ross Procedure. Conklin, Lori D.; Reardon, Michael J. // Texas Heart Institute Journal;2001, Vol. 28 Issue 3, p186 

    Focuses on Ross procedure, the use of the autologous pulmonary valve for replacement of a diseased aortic valve that was introduced by Donald Ross of Great Britain in 1967. Technical aspects of the procedure; Part of the reason for the delay in acceptance of the surgical procedure; Conclusion.

  • Early and late outcomes of 1000 minimally invasive aortic valve operations. Tabata, Minoru; Umakanthan, Ramanan; Cohn, Lawrence H.; Bolman, Ralph Morton; Shekar, Prem S.; Chen, Frederick Y.; Couper, Gregory S.; Aranki, Sary F. // European Journal of Cardio-Thoracic Surgery;Apr2008, Vol. 33 Issue 4, p537 

    Abstract: Objective: Minimal access cardiac valve surgery is increasingly utilized. We report our 11-year experience with minimally invasive aortic valve surgery. Methods: From 07/96 to 12/06, 1005 patients underwent minimally invasive aortic valve surgery. Early and late outcomes were analyzed....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics