TITLE

THE SPECIFICITY OF THE INFLAMMATORY RESPONSE AFTER CARDIAC SURGERY PERFORMED UNDER REMOTE ISCHEMIC PRECONDITIONING

AUTHOR(S)
Datsenko, S. V.; Bautin, A. E.; Tashkhanov, D. M.; Marichev, A. O.; Bakanov, A. Yu.; Malaya, E. Ya.; Naumenko, V. S.; Gordeev, M. L.
PUB. DATE
September 2015
SOURCE
Vestnik Sankt-Peterburgskogo Universiteta, Seriia 11: Medicina;2015, Issue 2, p9
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
The aim. to estimate whether remote ischemic preconditioning (RIpe) affects the inflammatory response and clinical course in patients undergoing aortic valve replacement (AVR). Materials and Methods. 48 patients aged 50 to 75 years which were scheduled for AVR due to aortic valve stenosis were included into the prospective, randomized study. Four groups were formed after randomization: 1) RIpe applied during propofol anesthesia (RIpcprop, n = 12), 2) RIpe applied during sevoflurane anesthesia (RIpcsevo, n = 12), 3) propofol anesthesia without RIpe (contRoLprop, n = 12), 4) sevoflurane anesthesia without RIpe (contRoLsevo, n = 12). RIpe protocol: three fiveminutes episodes of simultaneous both lower limbs ischemia with fiveminutes reperfusion intervals. IL6, IL8 and cRp levels were assessed prior to induction of anesthesia, at 30 min, 6, 12, 24 and 48 hours after the cessation of cpb. significant differences were assessed by the nonparametric MannWhitney and Fisher's exact tests. Results. There were no statistical differences in cRp, IL8 and IL6 concentrations between the RIpe and contRoL groups at 30 min, 12 h and 48 h after cpb. Unexpectedly we found significantly higher IL8 activity in the RIpe group at 24 h after cpb. It was 11,9(10,3; 14,9) pg/ml vs. 8,1 (5,7; 10,5) pg/ml in the contRoL group (p =0,01). significant excess concentrations of IL8 at 24 h were found when RIpe applied during sevoflurane anesthesia: 12,3 (10,6, 14,4) pg/mL in RIpcsevo group vs 6.2 (4,8, 11,1) pg/ ml in contRoLsevo group (p = 0,02), there were no differences in IL8 concentrations between RIpcprop and contRoLprop groups in all time points. Conclusion. This pilot study indicates surprisingly that RIpe may enhance the inflammatory response after AVR.
ACCESSION #
110378169

 

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